MK-777 (Acetamoren)
Price range: $70.00 through $110.00
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
Key Specifications
| Parameter | Specification / Details |
|---|---|
| Primary Compound Name | Acetamoren (MK-777) |
| CAS Registry Number | 950841-87-9 |
| IUPAC Designation | (R)-2-Acetamido-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4′-piperidin]-1′-yl)-1-oxopropan-2-yl)-2-methylpropanamide |
| Synonyms / Trade Names | N-Acetyl Ibutamorelin, MK-777 |
| PubChem CID | Novel Derivative (Not yet formally assigned in primary CID databases) |
| Molecular Formula | C₂₉H₃₈N₄O₆S |
| Molar Mass / Weight | 570.70 g/mol |
| Physical Appearance | White crystalline powder (raw) / Clear liquid (suspended) |
| Solubility Profile | Soluble in DMSO, PEG 400, and Ethanol. Insoluble in water. |
| Tested Purity | ≥98% via HPLC |
| Active Ingredient (Total) | [e.g., 600mg per vial or 60 capsules] |
| Dry / Powder Formulations | [e.g., 10mg or 20mg pressed capsules/tablets] |
| Liquid / Solution Concentrations | [e.g., 20mg/mL in a PEG 400 / Ethanol carrier] |
| Alternative Formulations | Ibutamoren (MK-677 – the non-acetylated parent compound) |
| Storage Guidelines | Store at room temperature (20°C to 25°C). Protect strictly from moisture, heat, and direct sunlight. |
| Estimated Shelf Life | 24 months from manufacture date. |
| Safety Documentation | Standard SDS available for Acetamoren |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. Investigated as a high-affinity, highly selective agonist of the ghrelin receptor (GHS-R1a) to evaluate mechanisms of growth hormone secretagogue activity and localized nutrient partitioning in in-vitro models. |
Foundational Scientific Overview
MK777 is a specialized research compound closely related to the spiroindoline class of ghrelin mimetics. As an experimental growth hormone secretagogue analog, it serves researchers examining the highly targeted upstream regulation of the somatotropic axis and isolated IGF-1 transcription without the typical downstream modulation of peripheral lipid metabolism.
At 4 Amino Labs, we provide this novel derivative in a highly purified format to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity.
Scientific Literature Reference: The ongoing synthesis of non-peptide secretagogues to isolate GH release from other neuroendocrine axes remains a critical area of molecular design. See: Patchett, A. A., et al. (1995). “Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.” Proceedings of the National Academy of Sciences, 92(15), 7001-7005.
Analytical Composition & Purity Standards
- Chemical Formula: Proprietary Spiroindoline Derivative
- Physical State: Fine Crystalline Solid
Our MK777 undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) to ensure a purity threshold of ≥ 99%. This analytical rigor ensures the absence of unreacted synthetic precursors.
Investigational Pathways
Researchers utilizing MK777 typically focus on the following biochemical mechanisms:
- Receptor Specificity: Evaluating the compound’s selective binding kinetics to GHSR1a variations in pituitary cellular models.
- Transcriptional Regulation: Observing the elevation of specific IGF-1 splice variants in isolated hepatic cells.
- Neuroprotection: Mapping the flux of anti-apoptotic markers in induced-stress neuronal assays.
Laboratory Handling & Stability Protocol
To maintain the molecular integrity of MK777, the following storage parameters are recommended:
- Thermal Regulation: Store in a strictly controlled, desiccated environment at room temperature.
- Photostability: Protect from direct UV exposure; storage in an opaque container is advised to prevent photodegradation.
- Contamination Control: Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.
Frequently asked questions
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A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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