KPV (10mg)
$65.00
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
Key Specifications
| Category | Parameter | Specification / Details |
|---|---|---|
| Identification & Nomenclature | Primary Compound Name | KPV (alpha-MSH Fragment) |
| CAS Registry Number | 80082-62-8 | |
| Sequence / IUPAC | Lys-Pro-Val | |
| Chemical & Physical Properties | Molecular Formula | C16H30N4O4 |
| Molar Mass / Weight | 342.43 g/mol | |
| Physical Appearance | White lyophilized (freeze-dried) solid/powder | |
| Solubility Profile | Highly soluble in Bacteriostatic Water and sterile water. | |
| Product Specifications | Tested Purity | ≥98% via HPLC |
| Active Ingredient (Total) | 10mg per vial | |
| Dry / Powder Formulations | Lyophilized powder | |
| Handling & Logistics | Storage Guidelines | Lyophilized: Store at -20°C for long-term stability. Protect from light.Reconstituted: Must be refrigerated at 2°C to 8°C. |
| Estimated Shelf Life | 24 months from manufacture date (lyophilized). | |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. Investigated for its potent anti-inflammatory properties, particularly evaluating the inhibition of NF-kB intracellular signaling pathways in mucosal and mast cell models. |
Foundational Scientific Overview
KPV (10mg) is a paramount subject within the field of localized anti-inflammatory research and mucosal healing. Synthesized as a highly stable tripeptide (Lysine-Proline-Valine) representing the C-terminal sequence of alpha-melanocyte-stimulating hormone (ɑ-MSH), it serves researchers examining the profound down-regulation of pro-inflammatory cytokines without the melanogenic (pigment-inducing) side effects of full-length MSH.
At 4 Amino Labs, we provide this highly purified compound to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity.
Scientific Literature Reference: The biochemical capacity of the KPV tripeptide to enter intestinal and epithelial cells via the PepT1 transporter and strongly inhibit NF-ΚB activation is highly documented in gastroenterological literature. See: Dalmasso, G., et al. (2008). “PepT1-mediated epithelial transport of the antimicrobial peptide KPV suppresses intestinal inflammation.” Gastroenterology, 134(1), 166-178.
Analytical Composition & Purity Standards
- Chemical Formula: C16H30N4O4
- Physical State: White Lyophilized Solid
Our KPV undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≧ 99%.
Investigational Pathways
Researchers utilizing KPV typically focus on the following biochemical mechanisms:
- NF-kappaB Inhibition: Evaluating the compound’s capacity to translocate into the nucleus and directly block the transcription of pro-inflammatory cytokines (IL-6, IL-8, TNF-$\alpha$).
- Mucosal Healing: Observing the accelerated repair of epithelial barriers in isolated intestinal or dermal cell cultures under induced inflammatory stress.
- Antimicrobial Modeling: Mapping the peptide’s targeted fungicidal and bacteriostatic effects in specific pathogen-exposed cellular assays.
Laboratory Handling & Stability Protocol
To maintain the molecular integrity of KPV, the following storage parameters are recommended:
- Thermal Regulation: Store in a strictly controlled, refrigerated, and desiccated environment.
- Photostability: Protect from direct UV exposure; storage in an opaque container is advised.
- Contamination Control: Utilize sterilized instruments and work within a laminar flow hood where possible.
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Frequently asked questions
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A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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